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There are several matches for 'protein DegS'.
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1072 matches
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organism
protein
1)
Homo sapiens
DNAJB2 - DnaJ homolog subfamily B member 2; Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock
protein
70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded
proteins
. Thereby, may regulate the aggregation and promote the functional recovery of misfolded
proteins
like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated
protein
deg
[...]
[a.k.a. ENSP00000375936, ENSP00000414796, ENST00000473750.5]
2)
Homo sapiens
DENND3 - DENN domain-containing
protein
3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter
proteins
and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in
protein
transport from recycling endosomes to lysosomes, regulating, for instance, the
deg
[...]
[a.k.a. UPI0001E8F5CE, DENND3-222, XM_017013241.1]
3)
Homo sapiens
STAMBP - STAM-binding
protein
; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM- CSF. Potentiates BMP (bone morphogenetic
protein
) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR
deg
[...]
[a.k.a. NP_001340896, O95630, AAI01468.1]
4)
Homo sapiens
PRNP - Major prion
protein
; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase
deg
[...]
[a.k.a. Q96E70, NP_898902, Q27H91]
5)
Mus musculus
Fmn2 - Formin-2; Actin-binding
protein
that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against
deg
[...]
[a.k.a. ENSMUST00000195300.1, CCDS48459.1, UPI00053BD69C]
6)
Mus musculus
Prnp - Major prion
protein
; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase
deg
[...]
[a.k.a. Prn-p, M30384, NM_001278256]
7)
Caenorhabditis elegans
acn-1 - Inactive angiotensin-converting enzyme-related
protein
; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic
protein
lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related
deg
[...]
[a.k.a. ACN1_CAEEL, Q65ZH6, Acn-1]
8)
Escherichia coli K12
degS - Serine endoprotease, periplasmic; A site-1 protease (S1P) that cleaves the peptide bond between 'Val-148' and 'Ser-149' in RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. When heat shock or other environmental stresses disrupt
protein
folding in the periplasm,
DegS
senses the accumulation of unassembled outer membrane porins (OMP) and then initiates RseA (anti sigma-E factor) degradation by cleaving its periplasmic domain, making it a substrate for subsequent cleavage by RseP. This cascade ultimately leads to the sigma-E-driven expression of a variety of factors deal [...]
[a.k.a. b3235, AAC76267.1, Q2M8X8]
9)
Escherichia coli K12
rseA - Anti-sigma factor; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate
protein
is first cut periplasmically (site-1 protease, S1P,
DegS
), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading [...]
[a.k.a. b2572, AAC75625.1, mclA]
10)
Escherichia coli K12
rseP - Inner membrane zinc RIP metalloprotease; A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on
DegS
-cleaved RseA to release the cytoplasmic domain of RseA, residue 'Val-148' of RseA may be required for this. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA. Can also cleave sequences in transmembrane regions of other
proteins
(such as LacY) as well as liberated signal peptides of beta-lactamas [...]
[a.k.a. b0176, AAC73287.1, 3ID1]
11)
Pasteurella multocida OH4807
AKD37618.1 -
Protein
DegS
; COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain.
[a.k.a. I926_01440, A0A0E3ZPP9, NZ_CP004391.1,
protein DegS
,
Protein DegS
, ...]
12)
Pseudomonas sp. RIT357
degS -
Protein
DegS
.
[a.k.a. BW43_02022, EZP66856.1, IPR009003,
protein DegS
,
Protein DegS
, ...]
13)
Thermosediminibacter oceani
Toce_0369 - COGs: COG4585 Signal transduction histidine kinase; InterProIPR005467:IPR016381:IPR003594:IPR008595:IPR 011712; KEGG: tte:TTE1682 sensory transduction histidine kinase; PFAM: Sensor
DegS
domain
protein
; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain
protein
; SMART: ATP-binding region ATPase domain
protein
; SPTR: Sensor
protein
DegS
; PFAM: Histidine kinase; Sensor
protein
DegS
; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
[a.k.a. ADL07150.1, WP_013275200.1, NC_014377.1]
14)
Thermanaeromonas toyohensis
SMB94853.1 - Two-component system, NarL family, sensor histidine kinase
DegS
; InterProIPR008595:IPR011712:IPR003594:IPR005467:IPR 016381:IPR004358; COGs: COG4585 Signal transduction histidine kinase; KEGG: pth:PTH_1443 sensor
protein
DegS
and signal transduction histidine kinase; SPTR: Sensor
protein
DegS
and signal transduction histidine kinase; SMART: ATP-binding region ATPase domain
protein
; PFAM: Sensor
DegS
domain
protein
; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain
protein
.
[a.k.a. SAMN00808754_1125, SMB94853, A0A1W1VNK1]
15)
Tissierellia bacterium KA00581
KXB43430.1 - Hypothetical
protein
; KEGG: bmh:BMWSH_0156 0.0041
degS
;
DegS
protein
; K07777 two-component system, NarL family, sensor histidine kinase
DegS
; Psort location: Cytoplasmic, score: 7.50.
[a.k.a. HMPREF3188_01492, KXB43430, A0A133YJT1]
16)
Syntrophobotulus glycolicus
Sgly_1796 - COGs: COG4585 Signal transduction histidine kinase; InterPro IPR008595: IPR011712: IPR003594; KEGG: dhd:Dhaf_2790 sensor
DegS
domain
protein
; PFAM: Sensor
DegS
; Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain; ATPase-like, ATP-binding domain; SPTR: Putative uncharacterized
protein
; PFAM: Histidine kinase; Sensor
protein
DegS
; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
[a.k.a. ADY56093.1, ADY56093, DegS sensor signal transduction histidine kinase]
17)
Hungateiclostridium thermocellum
Cthe_1268 - KEGG: cce:Ccel_1864 sensor
DegS
domain
protein
; PFAM: Sensor
DegS
domain
protein
; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain
protein
; SMART: ATP-binding region ATPase domain
protein
.
[a.k.a. ABN52500.1, 0000155, IPR011712]
18)
Ruminiclostridium papyrosolvens DSM 2782
Cpap_3055 - KEGG: cce:Ccel_1864 sensor
DegS
domain
protein
; PFAM: Sensor
DegS
domain
protein
; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain
protein
; SMART: ATP-binding region ATPase domain
protein
.
[a.k.a. EGD48632.1, NZ_ACXX02000003.1, WP_004617821.1]
19)
Dehalogenimonas lykanthroporepellens
ADJ25935.1 - PFAM: thiamine pyrophosphate
protein
domain
protein
TPP-binding; KEGG:
deg
:DehalGT_0620 thiamine pyrophosphate
protein
domain
protein
TPP-binding
protein
.
[a.k.a. Dehly_0626, 1.2.7.1, ADJ25935]
20)
Dehalogenimonas lykanthroporepellens
ADJ26350.1 - PFAM: Mg2 transporter
protein
CorA family
protein
; KEGG:
deg
:DehalGT_0364 Mg2 transporter
protein
CorA family
protein
.
[a.k.a. Dehly_1049, dly:Dehly_1049, Mg2 transporter protein CorA family protein]
1072 matches
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